The Biology of Cancer
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"Socks Before Shoes: How Cells Keep Track of Their Chromosomes"
Dr. Andrew Murray
Professor of Biology, Molecular and Cellular Biology
Director, Center for Genomics Research
Every time a cell divides, it runs the risk of generating
daughters with too few or too many chromosomes. These mistakes play a crucial
role in many cancers. Dr. Murray will discuss the mechanisms by which cells
make sure that their chromosomes are properly lined up on the cell division
machinery before the cell divides.
"Subcellular Crisis Prevention: How Cells Detect Damaged Chromosomes"
Dr. Matthew Michael
Assistant Professor of Molecular and Cellular Biology
Dr. Michael will discuss the mechanisms and pathways
that function to maintain stability of the genome. His lecture will include
an overview of research being conducted to understand DNA damage checkpoint
"Targeted Therapy for Cancer"
Dr. Harold Burstein
Assistant Professor of Medicine, Harvard Medical School
Clinician and Researcher, Dana Farber Cancer Institute
New cancer treatments are being evaluated that take
advantage of a better understanding of the biology of cancer cell growth. Dr.
Burstein will focus on "targeted" therapies for cancer and new drugs that are
changing our treatment strategies. The use of hormonal therapies, growth factor
receptor inhibitors, and angiogenesis inhibitors will be highlighted.
"Molecular Pathogenesis of Breast Cancer"
Dr. Joan Brugge
Professor of Cell Biology, Harvard Medical School
Dr. Brugge will discuss the pathogenesis of breast
cancer and studies to define the molecular events that control the initiation
and progression of breast cancer. In vitro models that mimic the behavior of
breast epithelial cells in vivo will be included in the discussion.
"The Host Response to Cancer: Friend or Foe?"
Dr. Glenn Dranoff
Associate Professor of Medicine, Harvard Medical School
and Researcher, Dana Farber Cancer Institute
The immune system plays dual roles during cancer
development. Host responses may inhibit tumor development and progression by
controlling infection, inflammation, and immunity. Alternatively, cancer cells
may subvert the host response to promote growth, attenuate death, and facilitate
invasion and metastasis. A more detailed understanding of host/tumor cell interactions
provides new opportunities for crafting cancer immunotherapy.
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